Our approach is quite different from conventional CE. Through gathering data from many
hundreds of points and using proprietary signal processing algorithms, our technology is able
to produce better quality results than competing CE systems. deltaDOT patented multipoint
detection system (512 detection points, each sampling at around 20 cycles per second) tracks
the passage of biomolecule bands across the detection window. The proprietary software
derived from particle physics can determine which of the signals relate to the sample and
which do not, thus eliminating any extraneous effects and inaccuracies. deltaDOT's advanced
signal processing technology combined with multi-point detection produces data of high quality
- sensitivity, resolution, quantification and repeatability.
hundreds of points and using proprietary signal processing algorithms, our technology is able
to produce better quality results than competing CE systems. deltaDOT patented multipoint
detection system (512 detection points, each sampling at around 20 cycles per second) tracks
the passage of biomolecule bands across the detection window. The proprietary software
derived from particle physics can determine which of the signals relate to the sample and
which do not, thus eliminating any extraneous effects and inaccuracies. deltaDOT's advanced
signal processing technology combined with multi-point detection produces data of high quality
- sensitivity, resolution, quantification and repeatability.
deltaDOT
HPCE instruments
Conventional Capillary Electrophoresis systems use single point detection. This means each
band of biomolecules is measured by just one detector. As a result biomolecules often need to
be 'labelled' with radiochemical, fluorescent, calorimetric, or luminescent compounds.
Conventional CE instruments cannot differentiate between extraneous interference, electrical
noise, light source fluctuations and other undesirable effects.
band of biomolecules is measured by just one detector. As a result biomolecules often need to
be 'labelled' with radiochemical, fluorescent, calorimetric, or luminescent compounds.
Conventional CE instruments cannot differentiate between extraneous interference, electrical
noise, light source fluctuations and other undesirable effects.
Cnventional CE
Vertexing demo
The core science behind LFII® originated in particle physics and is now being applied by
deltaDOT to biochemical analysis using Capillary Electrophoresis. The key to LFII® is the use
of a multi-pixel photo diode array (PDA) and the processing of the acquired signals. This large
data set is analysed by acquiring data from each band of biomolecules as it traverses each
pixel at a specific time point allowing for a distance-time correlation to be achieved. The
system measures the time it takes for any one band of biomolecules to traverse the detector
array and the software enables the molecular weight or charge-to-mass ratio to be calculated
from its velocity. This greatly improves signal-to-noise ratio offering molecular imaging which
outperforms single point detection systems. The deltaDOT system only works with the signals
that intersect the Vertex enabling LFII® to discriminate between system background noise - the
technique known as Vertexing.
deltaDOT to biochemical analysis using Capillary Electrophoresis. The key to LFII® is the use
of a multi-pixel photo diode array (PDA) and the processing of the acquired signals. This large
data set is analysed by acquiring data from each band of biomolecules as it traverses each
pixel at a specific time point allowing for a distance-time correlation to be achieved. The
system measures the time it takes for any one band of biomolecules to traverse the detector
array and the software enables the molecular weight or charge-to-mass ratio to be calculated
from its velocity. This greatly improves signal-to-noise ratio offering molecular imaging which
outperforms single point detection systems. The deltaDOT system only works with the signals
that intersect the Vertex enabling LFII® to discriminate between system background noise - the
technique known as Vertexing.
PEREGGRINE I
HPCE instrument
13 August 2012 Texas A&M System Awarded National Center for
Innovation
deltaDOT Ltd. is a partner in BARDA funded international
consortium
$285.6 million public-private partnership to enhance the nation’s
biosecurity preparedness and create jobs in Texas
COLLEGE STATION, Texas – John Sharp, chancellor of The Texas
A&M University System, today announced that the A&M System
has been awarded a contract to develop one of three U.S.
Department of Health and Human Services Centers for
Innovation in Advanced Development and Manufacturing. The
$285.6 million contract includes an initial investment of $176.6
million from the U.S. government, with the remainder cost-
shared by commercial and academic proposal partners.
2nd August 2012 deltaDOT Ltd. awarded Technology Strategy
Board grant
deltaDOT Ltd, announced today that the government-backed
Technology Strategy Board has awarded the company a feasibility
study award for the applicationof its Label Free Intrinsic Imaging
technology to bioprocess analytics. The project “Rapid low cost
formulation screening for protein self-interaction based on High
Performance Capillary Electrophoresis” is a feasibility study that
addresses the need for a costeffective,
user-friendly, automated platform technology allowing rapid
screening for protein selfinteractions.
A&M University System, today announced that the A&M System
has been awarded a contract to develop one of three U.S.
Department of Health and Human Services Centers for
Innovation in Advanced Development and Manufacturing. The
$285.6 million contract includes an initial investment of $176.6
million from the U.S. government, with the remainder cost-
shared by commercial and academic proposal partners.
2nd August 2012 deltaDOT Ltd. awarded Technology Strategy
Board grant
deltaDOT Ltd, announced today that the government-backed
Technology Strategy Board has awarded the company a feasibility
study award for the applicationof its Label Free Intrinsic Imaging
technology to bioprocess analytics. The project “Rapid low cost
formulation screening for protein self-interaction based on High
Performance Capillary Electrophoresis” is a feasibility study that
addresses the need for a costeffective,
user-friendly, automated platform technology allowing rapid
screening for protein selfinteractions.
LABEL FREE
INTRINSIC
IMAGING
LFII®
Reliability and automation of PEREGRINE I is suitable for unattended (e.g. overnight)
operation which can increase productivity. deltaDOT Label Free (LFII®) system’s superior
performance and sensitivity obviate the need for expensive (and often toxic) chemical labels.
Design ergonomics, user friendly interface and unsurpassed results in one compact bench top
instrument often resulting in reducing the laboratory costs and overheads.
operation which can increase productivity. deltaDOT Label Free (LFII®) system’s superior
performance and sensitivity obviate the need for expensive (and often toxic) chemical labels.
Design ergonomics, user friendly interface and unsurpassed results in one compact bench top
instrument often resulting in reducing the laboratory costs and overheads.